# CJC-1295 Doses Used in the Published Studies | CJC-1295 Review

> CJC-1295 dosage in the research literature: the 30/60/90 microgram/kg human PK doses and the 2 microgram murine dose, framed strictly as research methodology — not a human recommendation. Cited.

What was administered, to which species, by which route, in the peer-reviewed record — stated as research methodology. CJC-1295 has no approved human use, so none of this is a recommendation.

## What doses were used in the published studies

The doses used in CJC-1295 research are a short, specific list — and they describe study design, not a dosing guide. In the human pharmacokinetic studies, single subcutaneous doses of 30, 60, or 90 micrograms/kg were administered to healthy adults [1][3]. In the GHRH-knockout mouse growth study, 2 micrograms per dose was given at 24-, 48-, or 72-hour intervals [4]. Those are the figures with peer-reviewed provenance.

Everything circulating beyond that list lives in a different evidence state. Community and clinic "protocols" for no-DAC Modified GRF 1-29 and for CJC-1295/ipamorelin commonly cite fixed 100-300 microgram doses, but these are not derived from controlled human trials [1]. This page reports the research doses and flags the protocol claims as unverified; it does not translate either into a human course of administration.

## Route, half-life, and study duration

The route across the published studies is subcutaneous injection, with intravenous administration used in the early GRF(1-29) pharmacokinetic work [10]. Oral bioavailability is negligible — CJC-1295 is a peptide and would be digested — so no oral route appears in the literature.

Duration of action is the dimension that depends entirely on variant, and it is covered in full under [pharmacokinetics and half-life](/pharmacokinetics). In brief: the DAC variant's estimated half-life is 5.8 to 8.1 days, with IGF-1 elevated up to about 28 days after multiple doses [1]; the no-DAC Modified GRF 1-29 is short-acting, on the timescale of native GHRH(1-29) clearance [8]. Study durations followed those kinetics — the human PK studies tracked GH and IGF-1 for one to several weeks after dosing to capture the long tail [1][3].

## Why the doses differ by variant

The studied doses cannot be read without the variant attached, because dosing frequency in the research tracked the half-life directly. The DAC variant's multi-day half-life (5.8 to 8.1 days) is what allowed the murine work to space doses out: 2 micrograms once every 24 hours fully normalized growth in GHRH-knockout mice, while every-48-to-72-hour dosing was progressively less effective [4][1]. That is a finding about a long-acting molecule, and it does not transfer to the short-acting no-DAC form, whose minutes-to-hours clearance implies a different administration logic entirely [8].

This is why importing a microgram figure from one variant to the other is a category error, and why this site keeps the [DAC vs no-DAC (Modified GRF 1-29)](/dac-vs-no-dac) distinction in front of any dose discussion. The 30/60/90 microgram/kg human figures are DAC-variant PK doses [1][3]; the fixed 100-300 microgram "protocol" numbers that circulate online are most often quoted for the no-DAC form or the ipamorelin pairing and have no controlled-trial provenance for either [1]. The honest summary is that the literature establishes what was administered in a handful of pharmacokinetic studies, and nothing more granular than that.

## How research handling actually works

### How much CJC-1295 should I take?

Published human PK studies used single subcutaneous doses of 30, 60, or 90 micrograms/kg [1][3]. These describe research dosing, not a human recommendation; CJC-1295 has no approved human use.

### How to reconstitute CJC-1295?

In research handling, the lyophilized peptide is reconstituted with bacteriostatic water and refrigerated; oral bioavailability is negligible, so the studied routes are subcutaneous (primary) and intravenous (early GRF(1-29) PK work) [10]. This describes laboratory handling, not human-use instructions.

### Where to inject CJC-1295?

The route used across the published studies is subcutaneous injection, with intravenous used in early GRF(1-29) pharmacokinetic work [10]. This reflects research methodology; CJC-1295 has no approved human administration.

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The CJC-1295 record read as a state machine — each figure logged to its study and tagged confirmed, the absent long-term human safety data left in plain view as the loudest state on the panel; no clinic behind the interface and nothing here dispensed or sold.